Effects of Topical Vitamin K, Vitamin K and Retinol, and Arnica on Post-Laser Bruising
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About
The objective of this study is to assess the comparative utility of topical formulations in hastening the resolution of skin bruising. For each subject, four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser. Randomization was used to assign one topical agent (5% vitamin K, 1% vitamin K and 0.3% retinol, 20% arnica or white petrolatum) to exactly one bruise per subject, which was then treated under occlusion twice a day for 2 weeks. A dermatologist rated bruises in standardized photographs immediately after bruise creation and at week 2.
Enrollment
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Volunteers
Inclusion criteria
- Age 20-60
- Subjects are in good health.
- Subjects have willingness and the ability to understand and provide informed consent for participation in the study.
Exclusion criteria
- Subjects who are currently using any anticoagulation therapy (Warfarin, Heparin, Aspirin)
- Subjects who have a history of bleeding disorders.
- Subjects who are unable to understand the protocol or to give informed consent
- Subjects with mental illness
- Subjects who are pregnant or nursing.
- Subjects who have active systemic or local infection
- Subjects with systemic or local skin disease.
- Subjects with systemic illness.
Trial design
Primary purpose
Allocation
Interventional model
Masking
16 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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