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Effects of Total Intravenous Anesthesia With Propofol-remifentanil Versus Inhalational Anesthesia With Sevoflurane on Quality of Recovery in Patients Undergoing Transsphenoidal Surgery for Pituitary Tumor

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Yonsei University

Status

Completed

Conditions

Pituitary Tumor

Treatments

Drug: inhalation anesthesia group
Drug: total intravenous anesthesia (TIVA)

Study type

Interventional

Funder types

Other

Identifiers

NCT02813044
4-2016-0344

Details and patient eligibility

About

A number of studies have compared the effects of total intravenous anesthesia(TIVA) versus inhalational anesthesia on perioperative period during transsphenoidal surgery. However, they have limitations especially for the phase of recovery after anesthesia: a fragmentary assessment. Quality of Recovery 40 (QoR-40) questionnaire was multi-dimensionally designed to assess the degree of recovery, specially after anesthesia and surgery. In this study, the investigators aim to compare the quality of recovery after inhalational anesthesia and after TIVA through QoR-40 questionnaire in patients undergoing transsphenoidal surgery for pituitary tumor under general anesthesia.

Enrollment

82 patients

Sex

All

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients over age 19
  • Scheduled to undergo transsphenoidal surgery for pituitary tumor
  • ASA class I and II

Exclusion criteria

  • Left ventricular ejection fraction < 55%
  • Third-degree atrioventricular block
  • Second-degree atrioventricular block (P:QRS ratio of 3:1 or higher)
  • Fever
  • History of myocardial infarction, stroke or cardiac surgery within the previous 1 year
  • Severe neurological disease
  • Use of sedative, opioid or sleep-inducing drugs
  • Allergic history of any study drug
  • Pregnancy

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

82 participants in 2 patient groups

TIVA group
Experimental group
Description:
Anesthesia is maintained with propofol during surgery
Treatment:
Drug: total intravenous anesthesia (TIVA)
inhalation anesthesia group
Active Comparator group
Description:
Anesthesia is maintained with sevoflurane during surgery
Treatment:
Drug: inhalation anesthesia group

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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