Effects of Total Knee Replacement on Early Postoperative Cognitive Function in Elderly Patients (POCD)

General Hospital of Ningxia Medical University

Status: Completed

Conditions: Perioperative Complications

Study type: Observational

Funder types: Other

Identifiers

NCT02387541

NZ10145

Details and patient eligibility

About

To investigate the effects of total knee replacement is harmful to Postoperative cognitive dysfunction

Full description

Postoperative cognitive dysfunction (POCD) is reported to occur after major surgery in elderly patients. They may especially experience problems in the weeks and months after surgery. Recent studies vary greatly in methods of evaluation and diagnosis of POCD, and the pathogenic mechanisms are still unclear. The investigators evaluated a large uniform cohort of elderly patients in a standardized approach after total knee replacement.

Enrollment: 100 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged ≥65 years;
• ASA I or Ⅱ;
• total knee replacement

Exclusion criteria

• Mini Mental State Examination [MMSE] score too low.
• Parkinson or other neurological disease causing functional impairment.
• Patients with a history of alcohol abuse (≥35 U per week) or daily use of anxiolytics were also excluded, as well as those with severe hearing or visual impairment.