Effects of Training Intensity on Physical Fitness and Body Composition in Cystic Fibrosis

University of Kiel

Status: Active, not recruiting

Conditions: Cystic Fibrosis

Treatments: Other: Moderate Continuous Intensity Training (MICT); Other: High Intensity Interval Training (HIIT)

Study type: Interventional

Funder types: Other

Identifiers

NCT05140967

ABW-2021-CF

Details and patient eligibility

About

Aim of the randomized controlled trial is to investigate the effects of endurance training with different intensities on physical performance, body composition and appetite regulation in people with cystic fibrosis.

Enrollment: 70 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• confirmed diagnosis of cystic fibrosis by at least 2 sweat tests and / or by the presence of two CF mutations,
• willingness to participate in and to comply with the research project procedure,
• written informed consent of patients,
• age ≥ 18 years,
• FEV1 of pred. ≥ 40%,
• Stable condition (as indicated by absence of one or more signs: new or increased haemoptysis, increased malaise, fatigue or lethargy, temperature over 38°C, weight loss, sinus pain and a decrease in pulmonary function by 10% or more)

Exclusion criteria

• Severe pulmonary exacerbation,
• cor pulmonale,
• musculoskeletal discomfort that makes a regular exercise training impossible,
• untreated CF-related diabetes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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70 participants in 2 patient groups

High Intensity Interval Training (A)

Experimental group

Description:

Exercise training with intermittent bouts of high intensity

Treatment:

Other: High Intensity Interval Training (HIIT)

Moderate Intensity Continous Training (B)

Experimental group

Description:

Exercise training with constant workload

Treatment:

Other: Moderate Continuous Intensity Training (MICT)