Effects of Transcranial Direct Current Stimulation in Refractory Chronic Migraine and Medication-overuse Headache

Dr Armando Perrotta, MD, PhD

Status: Unknown

Conditions: Chronic Migraine; Medication Overuse Headache

Treatments: Device: Anodal transcranial direct current stimulation; Device: Sham transcranial direct current stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT01752439

tDCSCMMOH1

Details and patient eligibility

About

The purpose of the study is to evaluate the efficacy of the transcranial direct current stimulation of the primary motor cortex (M1) in patients affected by refractory chronic migraine (coded as 1.5.1 in the international headache classification 2nd edition, 2004) and medication-overuse headache (coded as 8.1) with migraine as primary headache.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic MIgraine or Medication Overuse Headache according to the diagnostic criteria set out in the 2nd edition of the International Classification of Headache Disorders refractory to treatment according to the Refractory Headache Special Interest Section of the American Headache Society (Schulman et al., 2008)

Exclusion criteria

• Other primary or secondary headaches.
• Any serious systemic or neurological disease or psychiatric disorder.
• Pregnancy or breastfeeding
• Previous or current use of other or similar devices for pain control
• Heart conduction and rhythm disorders
• Cranial surgery
• Other pain conditions, accordingly with current guidelines

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

30 participants in 3 patient groups

Anodal transcranial direct current stimulation

Experimental group

Description:

Anodal transcranial direct current stimulation

Treatment:

Device: Anodal transcranial direct current stimulation

Sham transcranial direct current stimulation

Sham Comparator group

Description:

Sham transcranial direct current stimulation

Treatment:

Device: Sham transcranial direct current stimulation

Control group

No Intervention group