Effects of Transcutaneous Electrical Nerve Stimulation on Cortical Excitability in the Primary Motor Cortex in Healthy Adults

Chang Gung University

Status: Completed

Conditions: Transcutaneous Electrical Nerve Stimulation

Treatments: Device: transcutaneous electrical nerve stimulation, TENS

Study type: Interventional

Funder types: Other

Identifiers

NCT02077595

101-3624B

Details and patient eligibility

About

Recently, non-invasive brain stimulation has become a powerful tool in both basic research and clinical application. Among several non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have received the most attention. About DC stimulation, the change of polarity could modulate the spontaneous neuronal activity and make effect on decision making, language, memory, sensory perception, and pain. In spite of that the concept of transcranial alternating current stimulation (tACS) is not novel, AC is relatively safe compared to DC, and researches have revealed that AC might potentially have the effect on the cortical excitability. However, there are still many areas about AC stimulation which remain unknown, such as mechanism, application, and potential influence on cortical excitability.

Enrollment: 24 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Healthy adults

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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24 participants in 3 patient groups

120Hz alternating current stimulation group

Active Comparator group

Treatment:

Device: transcutaneous electrical nerve stimulation, TENS

5Hz alternating current stimulation group

Active Comparator group

Treatment:

Device: transcutaneous electrical nerve stimulation, TENS

sham alternating current stimulation group

Sham Comparator group

Treatment:

Device: transcutaneous electrical nerve stimulation, TENS