Effects of Unloading on Muscle Mass

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Physical Inactivity; Immobilization

Treatments: Behavioral: unloading

Study type: Interventional

Funder types: Other

Identifiers

NCT00936039

MEC-09-3-011

Details and patient eligibility

About

In the present study, the effects of 3 weeks of unloading on muscle mass and muscle fiber characteristics will be determined. In addition, the effects of 6 weeks of recovery will be assessed.

Enrollment: 15 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• BMI < 30 kg/m2

Exclusion criteria

• Use of medication that may affect haemostasis
• Subjects with (recent) musculoskeletal/orthopaedic disorders known to affect the outcome of the study or that compromise their ability to walk with crutches
• Subjects with metal implants in their lower limbs
• Subjects with known cardiovascular and/or haemostasis disorders
• Subjects with known severe hypertension

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

unloading

Experimental group

Description:

2 weeks of unloading

Treatment:

Behavioral: unloading