Effects of Upper Extremity-Focused Neuromuscular Training in People With Multiple Sclerosis

Istanbul Aydın University

Status: Not yet enrolling

Conditions: Multiple Sclerosis

Treatments: Other: Neuromuscular Exercise Training; Other: Conventional Exercise Training

Study type: Interventional

Funder types: Other

Identifiers

NCT06712342

2024/125

Details and patient eligibility

About

The effectiveness of upper extremity focused neuromuscular exercise training in early stage people with MS will be investigated. People with MS enrolled in the study will be randomly assigned to three groups: Neuromuscular Exercise Group (NEG), Conventional Exercise Group (CEG), and Control Group (CG). All three groups will be assessed with primary and secondary outcome measures at baseline, week 8, and week 12. NEG, CEG, and CG will be initially assessed for upper extremity function, cognitive function, lower extremity function, grip strength, proximal muscle strength, sensation, coordination, fatigue, postural sway, and core muscle strength and endurance. Then, NEG will receive clinically supervised upper extremity focused neuromuscular exercise training with a minimum of 60 minutes of session time, 2 days a week for 8 weeks. This exercise training includes steps for postural control, weight transfer, proximal and distal muscle strengthening, proprioception, coordination and reaction speed. Similarly, CEG will receive clinically supervised traditional upper extremity exercise training, twice a week for 8 weeks, with a minimum of 60 minutes of session time. This exercise training includes strengthening with the band and manuel dexterity exercises. In both groups, stretching and mobility exercises will be added to the warm-up and cool-down exercises before and after the program. During this process, CG will be on the waiting list. At the end of 8 weeks, all three groups will be re-evaluated. After the exercise training, follow-up will be done and evaluations will be repeated in the 12th week. This study will provide evidence on the effects of upper extremity-focused neuromuscular exercise training on physical and cognitive functions in early-stage people with MS compared to traditional treatment approaches.

Enrollment: 72 estimated patients

Sex: All

Ages: 18 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Definite MS according to McDonald criteria,
• 18-64 years
• RRMS,
• EDSS < 4,
• Minimal or moderate upper extremity involvement

Exclusion criteria

• Having an attack in the last three months,
• Mini Mental Test <24 or visual deficit,
• Other medical conditions accompanying MS (cardiac, orthopedic or rheumatic, etc.),
• Being pregnant or breastfeeding,
• Doing regular exercise - receiving physiotherapy,
• Having spasticity of 2 or more in the upper extremity

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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72 participants in 3 patient groups

NEG

Experimental group

Description:

Upper Extremity Focused Neuromuscular Exercise Training

Treatment:

Other: Neuromuscular Exercise Training

CEG

Active Comparator group

Description:

Traditional Upper Extremity Exercise Training

Treatment:

Other: Conventional Exercise Training

CG

No Intervention group

Description:

Control Group