Effects of Ursodeoxycholic Acid on Graft Recovery Early After Adult Liver Transplantation

Shanghai Jiao Tong University School of Medicine

Status: Completed

Conditions: Liver Transplantation; Cholestasis; Ischemia-reperfusion Injury

Treatments: Drug: ursodeoxycholic acid; Drug: identical-appearing placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01073202

SFPH05B41

Details and patient eligibility

About

This study is designed to investigate the possible beneficial effects of UDCA on liver graft recovery early after adult liver transplantation.

Enrollment: 112 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All liver transplant patients in our center between May 2005 and April 2008 were potentially eligible for enrollment

Exclusion criteria

• Age less than 18 years
• Treatment with UDCA within one month before operation
• Inability to provide written informed consent prior to study entry
• Non-liver organ(s) failure prior to entry

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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112 participants in 2 patient groups, including a placebo group

ursodeoxycholic acid

Active Comparator group

Treatment:

Drug: ursodeoxycholic acid

identical-appearing placebo

Placebo Comparator group

Treatment:

Drug: identical-appearing placebo