Effects of Vitamin D Supplementation on Muscle Function Among Grave's Disease Patients

Frontier Medical and Dental College, Abbotabad

Status: Completed

Conditions: Graves Disease

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Vitamin D supplements

Study type: Interventional

Funder types: Other

Identifiers

NCT06451016

3389

Details and patient eligibility

About

Introduction:

A deficit in vitamin D may be involved in the development and presentation of Graves' disease (GD). Lack of vitamin D and GD are linked to deteriorating quality of life (QoL) and weakening of the muscles. Our goal was to look at the possible advantages of vitamin D supplementation for the improvement of thyroid-related QoL and muscle function in GD patients, as well as the possible drawbacks of anti-thyroid drugs (ATD).

Methodology:

A multicenter randomized controlled experiment with single-blinding was carried out with 48 patients who had been diagnosed with Graves' illness. The participants were split into two groups n=24 patients in each group. In addition to standard ATD, Group A received either 70 μg (2800 IU) of vitamin D daily or a corresponding placebo. Investigator measured muscular function and isometric strength at baseline, three, and nine months.

Enrollment: 48 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Grave's Disease
• either starting or about to start anti-thyroid medication (ATD)

Exclusion criteria

• Chronic granulomatous disease
• hypercalcemia
• poor renal function (eGFR < 45 ml/min)
• the presence of malignant disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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48 participants in 2 patient groups, including a placebo group

Vitamin D group

Experimental group

Treatment:

Dietary Supplement: Vitamin D supplements

Control Group

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo