Effects of Weight on Inflammation and Colon Cancer Risk

Tufts University

Status: Completed

Conditions: Colorectal Cancer

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT02884024

10103

Details and patient eligibility

About

An observational study designed to compare colonic cytokine concentrations in lean versus obese individuals

Full description

An observational study was performed on 43 individuals undergoing routine screening colonoscopy, some of whom were lean and some who were obese. They had weight, height, and waist-hip ratio measured at the time of colonoscopy and had additional colonic biopsies to measure colonic cytokines.

Enrollment: 43 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Caucasian
2. undergoing clinically-indicated screening colonoscopy
3. BMI< or = 25, or 30+

Exclusion criteria

1. past history of cancer (except non-melanoma skin cancer)
2. a polyposis syndrome
3. any current or chronic inflammatory disease or infection
4. incapable of providing valid informed consent

Trial design

43 participants in 3 patient groups

lean

Description:

healthy subject undergoing routine screening colonoscopy, BMI\< or = 25

Treatment:

Other: no intervention

mildly obese

Description:

healthy subject undergoing routine screening colonoscopy, BMI 30-33.9

Treatment:

Other: no intervention

moderate-to-severe obese

Description:

healthy subject undergoing routine screening colonoscopy, BMI 34+

Treatment:

Other: no intervention