Effects of Whey Protein Consumption by Patients Waiting for Liver Transplantation

Federal University of Minas Gerais

Status: Unknown

Conditions: Nutrition Disorders; Liver Disease

Treatments: Dietary Supplement: Whey protein

Study type: Interventional

Funder types: Other

Identifiers

NCT02901119

CAAE-27430714.8.0000.5149

Details and patient eligibility

About

Malnutrition is prevalent among chronic liver disease patients. Inadequate ingestion and/or metabolic alterations modify the body composition and biological functions. The purpose of this study is to determine whether whey protein comsumption, due to amino acid profile, digestibility and bioactive compounds may be beneficial for patients waiting for liver transplantation

Full description

A randomized, double-blind, intervention study in which patients are randomly assigned to receive packages of 20g of whey protein (WP) or casein (CA) to take twice a day (20g in the morning and 20g at night), as a supplement, during 15 days. They are monitored weekly by calls. Regular usual diet is maintained. Patients underwent muscle functionality assessment by handgrip dynamometry and 6-min. walking test and, the inflammatory response by plasmatic cytokines. All tests are performed at the beginning and the end of intervention.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic liver disease, liver transplantation

Exclusion criteria

• Children, illiterate, elderly, renal failure

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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30 participants in 2 patient groups

Whey protein

Experimental group

Description:

Patients are instructed to consume 20g of whey protein in the morning and 20g at night, during 15 days, as a supplement. Their regular usual diet is maintained.

Treatment:

Dietary Supplement: Whey protein

Casein

Active Comparator group

Description:

Patients are instructed to consume 20g of casein in the morning and 20g at night, during 15 days, as a supplement. Their regular usual diet is maintained.

Treatment:

Dietary Supplement: Whey protein