Effects of Whole-Body Vibration Exercise on Serum IGF-1 in Fibromyalgia

Institut Nacional d'Educacio Fisica de Catalunya

Status: Completed

Conditions: Fibromyalgia; Hormonal Responses to Exercise in Patients With Fibromyalgia.

Treatments: Device: Placebo Whole-body vibration exercise; Device: Vibratory platform, PowerPlate®, Badhoevendorp, Netherlands

Study type: Interventional

Funder types: Other

Identifiers

NCT00650715

WBVIGF1FM

Details and patient eligibility

About

The purpose of this study was to investigate the acute and chronic effect of whole-body vibration exercise on serum insulin-like growth factor-1 levels in women with fibromyalgia (FM). It was hypothesized that women with FM would exhibit an increase in IGF-1 following both acute and chronic WBV. Twenty-four women with FM were randomized into two groups: Vibration Group (VG) and Control Group (CG). The VG underwent a protocol with WBV exercise twice a week for a total of six weeks, whereas the CG performed the same protocol without vibratory stimulus. Both groups continued with their usual pharmacological treatment. Serum IGF-1 levels were determined using Enzyme-Linked Immunosorbent Assay (ELISA). To test the effect of chronic WBV, serum IGF-1 measurements were taken at baseline and at weeks 1,3, and 6 of intervention. To test the effect of acute WBV, within week 1, serum IGF-1 measurements were taken before and immediately following a session of WBV.

Enrollment: 24 patients

Sex: Female

Ages: 35 to 69 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed of fibromyalgia according to the American College of Rheumatology criteria for at least three years.

Exclusion criteria

• Orthopedic limitation, or cardiovascular, pulmonary, or metabolic disease that would preclude exercise.
• Participation in any other study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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24 participants in 2 patient groups, including a placebo group

VG

Active Comparator group

Description:

Vibration Group (VG) underwent a protocol with whole-body vibration exercise twice a week for a total of six weeks. The group continued with their usual pharmacological treatment.

Treatment:

Device: Vibratory platform, PowerPlate®, Badhoevendorp, Netherlands

CG

Placebo Comparator group

Description:

The Control Group (CG) underwent the same protocol of exercises than VG but without vibratory stimulus. The CG continued with their usual pharmacological treatment.

Treatment:

Device: Placebo Whole-body vibration exercise