Effects of Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Cytokines

Assiut University

Status and phase: Completed; Phase 4

Conditions: Endometrial Adenocarcinoma

Treatments: Drug: Ketamine; Drug: bupivacaine; Drug: dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT03164590

388

Details and patient eligibility

About

This study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on inflammatory cytokine response after total abdominal hysterectomy.

Enrollment: 60 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II patients
• age range (18-60) years,
• weight (50- 90) kg

Exclusion criteria

• allergy to study drugs
• significant cardiac disease
• respiratory disease
• renal disease
• hepatic disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 3 patient groups, including a placebo group

ketamine

Active Comparator group

Treatment:

Drug: Ketamine

dexmedetomidine

Active Comparator group

Treatment:

Drug: dexmedetomidine

bupivacaine

Placebo Comparator group

Treatment:

Drug: bupivacaine

Drug: dexmedetomidine

Drug: Ketamine