Effects of Xanthohumol on Resting Energy Expenditure and Substrate Oxidation in Healthy Women

University of Bonn

Status: Completed

Conditions: Resting Energy Expenditure

Treatments: Dietary Supplement: Placebo; Dietary Supplement: micellar solubilized Xanthohumol

Study type: Interventional

Funder types: Other

Identifiers

NCT05711212

XN REE

Details and patient eligibility

About

The aim of this study is to investigate the effects of Xanthohumol on resting energy expenditure and substrate oxidation in healthy women. It is assumed that resting energy expenditure and fatty acid oxidation is higher after Xanthohumol ingestion.

Full description

In a crossover design, 16 healthy young women ingest 172 mg micellar solubilized Xanthohumol or placebo in a randomized fashion. During an observational period of 3 hours, the acute effects of Xanthohumol on the resting energy expenditure and substrate oxidation is determined by respiratory gas analysis. An additional 30-minute determination of the resting energy expenditure and substrate oxidation is executed 24 hours after Xanthohumol ingestion. The wash-out period will be 28 days.

Enrollment: 16 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI: 18,5 - 24,9 kg/m2
• metabolically healthy
• written consent

Exclusion criteria

• smoking
• low or high blood pressure
• dyslipidemia
• insulin resistance or diabetes mellitus type 1 or type 2
• gastrointestinal diseases (e.g. food intolerances or allergies)
• liver, kidney and/or thyroid diseases
• hepatitis B or C, HIV Infection
• chronic inflammatory diseases
• disordered eating
• psychological diseases
• alcohol and/or drug abuse
• use of medication
• pregnancy or lactating
• participation in another intervention study
• irregular menstrual cycle
• more than 6 hours of sports per week

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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16 participants in 2 patient groups, including a placebo group

Xanthohumol

Experimental group

Description:

single dose of 172 mg of micellar solubilized Xanthohumol

Treatment:

Dietary Supplement: micellar solubilized Xanthohumol

Placebo

Placebo Comparator group

Description:

Polysorbat 80 (E433)

Treatment:

Dietary Supplement: Placebo