Effects of Zinc Supplementation on Anthropometric Factors, Apelin and Inflammatory Markers in Obese Individuals

National Nutrition and Food Technology Institute

Status and phase

Completed

Phase 3

Phase 2

Conditions

Obesity

Treatments

Dietary Supplement: zinc sulfate

Other: corn starch

Study type

Interventional

Funder types

Other

Identifiers

NCT02516475

055570

Details and patient eligibility

About

To study the effects of zinc supplement on anthropometric factors, Apelin and inflammatory markers in obese individuals, 50 obes person who referred to Diet and Nutrition clinic of Shahid Beheshti University of Medical Sciences will be randomly allocated to receive 50 mg zinc capsules or placebos for 15 weeks; both groups will be advised to adherence the investigators' diet . At the first and the end of the intervention,weight, body mass index (BMI), waist circumference, fat mass and lean body mass, concentration of zinc, albumin, hs-CRP, TNF-α and plasma apelin will be assessed and compared between groups.

Enrollment

50 patients

Sex

All

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age of 18 to 45 years
Non-smoking
Body Mass Index (BMI) more than 30

Exclusion criteria

Pregnancy, lactation or menopause in women
History of liver disease, kidney, thyroid, diabetes and other metabolic diseases
Use of drugs interfering with lipid profile, blood-thinning drugs, beta-blockers
Patients with immune deficiency
Use of zinc, calcium and iron supplement in the last 2 months
Use of weight loss medication or special diet
Following program to lose weight in recent 2 months
Recent surgery