Effects on Experimental Dyspnea of High Flow Nasal Cannula (EDEN)

Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil

Status: Completed

Conditions: Healthy Volunteers; Dyspnea

Treatments: Device: Optiflow with an inspired fraction of oxygen of 21%; Device: Optiflow with an inspired fraction of oxygen of 100%

Study type: Interventional

Funder types: Other

Identifiers

NCT03469037

2018-A00178- 47

Details and patient eligibility

About

To develop an experimental model of dyspnea by external thoraco-abdominal elastic strapping at rest in order to study the mechanisms involved in the relief of dyspnea by the administration of high flow by nasal cannula (HFNC).

Full description

This study will measure the effect of HFNC on an experimental model of dyspnea induced by thoraco-abdominal elastic strapping on healthy subjects at rest.

The study will also compare the effects on dyspnea of the administration of high flow nasal cannula with and without oxygen added.

Enrollment: 32 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers

Exclusion criteria

• chronic pathology
• active smokers
• anxiety disorder
• allergy to latex
• protected adult
• woman declared herself pregnant

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

32 participants in 2 patient groups

Oxygen first

Experimental group

Description:

Optiflow with an inspired fraction of oxygen of 100% in the first seance Optiflow with an inspired fraction of oxygen of 21 % in the second seance

Treatment:

Device: Optiflow with an inspired fraction of oxygen of 100%

Device: Optiflow with an inspired fraction of oxygen of 21%

Air first

Experimental group

Description:

Optiflow with an inspired fraction of oxygen of 21 % in the first seance Optiflow with an inspired fraction of oxygen of 100 % in the second seance

Treatment:

Device: Optiflow with an inspired fraction of oxygen of 100%

Device: Optiflow with an inspired fraction of oxygen of 21%