Effects on Recovery of Postoperative Gastrointestinal Function With Multimodal Analgesia

National Taiwan University

Status: Not yet enrolling

Conditions: Gastrointestinal Recovery

Treatments: Drug: Placebo; Drug: Tenoxicam

Study type: Interventional

Funder types: Other

Identifiers

NCT04314310

201912245RINB

Details and patient eligibility

About

breast cancer surgery is associated with a high incidence of persistant postsurgical pain (PPSP). The aim of the study was to evluate the impact of intravenous Tenoxicam on acute and PPSP, analgesic requirements and gastrointestinal recovery in patients undergoing surgery for breast cancer.

Full description

thrity patients participated in this randomized, single-blined study. Before and at the postoperative day 1, the bowel function (orocecal transmit time) were measured. Before induction of general anesthesia, patients recieved a bolus of intravenous Tenoxicam or an equal volume of saline (control group). Pain score and opioid consumption were recorded in the postoperative period and then daily for 1 week.

Enrollment: 30 estimated patients

Sex: Female

Ages: 40 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I to II Breast cancer patients Mastectomy or wide local excision + axillary note dissection

Exclusion criteria

• Preexisting malignancy Chronic infection Previous pain condition Diabetes Thyroid disorder Severe cardiac, renal or hepatic disease Previous breast surgery Psychiatric illness Neurological disease Contraindication for tenoxicam or morphine use

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

Tenoxicam

Active Comparator group

Description:

nonsteroidal anti-inflammatory drug (NSAID)

Treatment:

Drug: Tenoxicam

placebo

Placebo Comparator group

Description:

equal volume of normal saline

Treatment:

Drug: Placebo