Effects os Physiotherapeutic Rehabilitation on Function Autonomic and Inflammatory in Patients With Long Covid (LongCovidRehab)

Universidade do Estado do Pará

Status: Not yet enrolling

Conditions: Long COVID; Cardiac Biomarkers; Heart Rate Variability (HRV); Inflammatory Biomarkers

Treatments: Other: physiothreapy protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT07046208

4252664 (Registry Identifier)

36459920400005174

Details and patient eligibility

About

Introduction: Long COVID is characterized by persistent symptoms that persist for weeks or months after the acute phase of infection, with a significant impact on the cardiovascular and autonomic systems. Objectives: This study aims to evaluate the effects of a physiotherapeutic rehabilitation protocol on cardiovascular autonomic modulation and on inflammatory and cardiac biomarkers in patients with Long COVID. Methodology: This is a controlled clinical trial, carried out in a cardiorespiratory rehabilitation outpatient clinic, involving individuals with a clinical diagnosis of Long COVID undergoing a protocol of 20 aerobic, anaerobic and respiratory rehabilitation sessions. Heart rate variability (HRV) variables will be analyzed using linear and non-linear methods, in addition to serum levels of CKMB, LDH, ferritin and C-reactive protein. Expected results: Rehabilitation is expected to provide an improvement in autonomic function and a reduction in inflammatory and cardiac markers, contributing to the understanding of the pathophysiological mechanisms of Long COVID and helping to propose evidence-based therapeutic strategies.

Enrollment: 58 estimated patients

Sex: All

Ages: 20 to 59 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• both sexes
• aged 20 and 59 years
• clinical evaluation and undergoing clinical follow-up of Post COVID-19.
• least one persistent COVID-19-related symptom.

Exclusion criteria

• incomplete data.
• presence of a pacemaker
• use of antihypertensive drugs that alter HRV
• persistent pulmonary alterations
• persistent desaturation
• anaemia or presence of reinfection.

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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58 participants in 1 patient group

Rehabilitation for long covid

Experimental group

Description:

Physioterapy protocol

Treatment:

Other: physiothreapy protocol