Efficacity of rTMS in Alcohol Dependance

Institut National de la Santé Et de la Recherche Médicale, France

Status

Completed

Conditions

Alcohol Dependance

Treatments

Other: rTMS (repetitive transcranial magnetic stimulation)

Study type

Interventional

Funder types

Other

Identifiers

NCT01569399

C10-21

2010-A00727-32 (Registry Identifier)

Details and patient eligibility

About

Prior research in substance dependence has suggested potential anti-craving effects of repetitive transcranial magnetic stimulation (rTMS) when applied to the dorsolateral prefrontal cortex (DLPFC). The aim of the investigators study was to investigate the effect of high frequency rTMS of the left dorsolateral prefrontal cortex compared to sham stimulation on craving and alcohol consumption.

Full description

Prior research in substance dependence has suggested potential anti-craving effects of repetitive transcranial magnetic stimulation (rTMS) when applied to the dorsolateral prefrontal cortex (DLPFC). The aim of our study was to investigate the effect of high frequency rTMS of the left dorsolateral prefrontal cortex compared to sham stimulation on craving and alcohol consumption.

150 detoxified patients are randomized either to a high frequency rTMS over the left DLPFC (n = 75) or a sham stimulations (n = 75). Alcohol craving is determined with the Obsessive Compulsive Drinking Scale. Patients are allocated to active and sham rTMS in a 1: 1 ratio, such that 75 patients received active and 75 patients sham rTMS to the left DLPFC (10 Hz frequency, total 10 sessions). The Alcohol Craving Questionnaire (ACQ-NOW) and the Obsessive Compulsive Drinking Scale (OCDS) are administered to measure the severity of alcohol craving at baseline, after the last rTMS session and day 15, M1, M3, M6 after. Alcohol drinking is evaluated with Timeline Followback (TLFB).

Enrollment

13 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosis of alcohol dependence syndrome according to DSM-IV criteria
Detoxified inpatients hospitalised for Alcohol Withdrawal for more than one week
Giving written informed

Exclusion criteria

Left-handed patients at the time of inclusion.
Age < 18 years
Withdrawal Assessment (CIWA-Ar) scores of > 5
Patients with major medical or neurological disorders or with a pacemaker or metal in any part of the body were excluded from the study.