Efficacity, Safety and Cost of Intravenous Morphine Titration Alone or Combined to Ketamine (KEMO)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Postoperative Pain

Treatments: Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT01146145

P020401

Details and patient eligibility

About

This is a randomised, controlled, double blinded study comparing in the postoperative setting the analgesic efficacy, the safety and the cost in two groups of patients receiving in the postanesthesia care unit either intravenous morphine titration alone or intravenous morphine titration combined to ketamine.

Full description

Randomised, controlled, double blinded study comparing in the postoperative setting the analgesic efficacy, the safety and the cost in two groups of patients receiving in the postanesthesia care unit either intravenous morphine titration alone or intravenous morphine titration combined to ketamine

Enrollment: 160 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 yrs
• scheduled surgery
• General anesthesia
• ASA I to III
• Able to use a VAS
• No psychological disorders, able to speak french

Exclusion criteria

• Age < 18 yrs
• Locoregional anesthesia or analgesia
• Allergia to morphine or ketamine
• Morphine or ketamine contraindication
• Pregnancy or breast-feeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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160 participants in 2 patient groups, including a placebo group

treatment

Experimental group

Description:

intravenous morphine titration combined to ketamine

Treatment:

Drug: Ketamine

placebo

Placebo Comparator group

Description:

morphine titration alone

Treatment:

Drug: Ketamine