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About
The primary objective of this study is to demonstrate the efficacy of T1225 eye drops versus placebo eye drops on the global ocular discomfort (VAS).
Full description
Currently, topical antibiotic ointments are used for blepharitis. They provide prolonged contact time with the lid margin but with little penetration into eyelid tissue. Azithromycin eye drops may offer on advantage over these preparations because azithromycin achieves sustained high concentration in various ocular tissues including the lid margin.
Patients will be treated during 7 days (1 drop twice daily the first day following by one drop once daily for 6 days) following by a period of 2 weeks without treatment. This therapeutic scheme will be repeated two times.
Efficacy will be evaluated by change from baseline (Day 0) to Day 63 ± 3 Days of the global ocular discomfort evaluation (VAS).
Enrollment
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Volunteers
Inclusion criteria
-Diagnosis of moderate to severe chronic blepharitis (posterior and/or anterior) in at least one eligible eye
Exclusion criteria
Primary purpose
Allocation
Interventional model
Masking
93 participants in 2 patient groups, including a placebo group
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Data sourced from clinicaltrials.gov
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