Efficacy and Safety of a Retinoid for the Treatment of Severe Chronic Hand Dermatitis
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Treatments
Details and patient eligibility
About
The purpose of the study is to determine the therapeutic effect of alitretinoin, a retinoid, on severe, therapy refractory chronic hand dermatitis.
Full description
Chronic hand dermatitis (CHaD) is a frequent and distressing disease. Conventional treatments yield mostly unsatisfactory results. In addition, chronic hand dermatitis leads to 2-5% of all applications for permanent disability pensions in some western countries. In a therapeutic dose finding study alitretinoin was clinically effective for patients with moderate to severe chronic hand dermatitis refractory to topical treatment.
Patients with severe refractory CHaD will be allocated either of two active treatments or placebo. The primary objective is to demonstrate the response rate based on physicians global assessment of the disease.
Sex
Ages
Volunteers
Inclusion criteria
- Chronic hand dermatitis, all types including hyperkeratotic, vesicular, fingertip dermatitis
- Lasting for 6 months since initial diagnosis
- Rated severe
- Refractory to standard therapy including non-medicated therapy and avoidance of irritants and allergens
- Refractory to topical steroids
Exclusion criteria
- Female patients who are pregnant or want to become pregnant
- Female patients of child bearing potential who cannot use or will not commit to using two effective forms of contraception simultaneously
- Patients whose disease is adequately controlled by standard non-medicated therapy and standard corticosteroid therapy
Trial design
Primary purpose
Allocation
Interventional model
Masking
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Data sourced from clinicaltrials.gov
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