Efficacy and Safety of Duloxetine Among Individuals With Depressive Disorder in a 12 Weeks Trial

Taichung Veterans General Hospital

Status: Completed

Conditions: Major Depressive Disorder

Treatments: Drug: Duloxetine

Study type: Interventional

Funder types: Other

Identifiers

NCT03121573

SF14216

Details and patient eligibility

About

The aim of this study was to investigate the effects of duloxetine on improvement of brain cortical activity in patients suffering from major depressive disorder using near infrared spectroscopy.

Enrollment: 30 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HAMD-17 more than 12 points
• Participants could understand this study and sign permit
• Participants could receive NIRS measurements
• Participants could comply with the protocol of the study

Exclusion criteria

• alcohol or substance abuse within 3 months of the study
• ever participate other clinical study related to duloxetine
• previous poor treatment effects of duloxetine
• concomitant use of MAOi within 14 days
• concomitant use of Linezolid
• with uncontrolled glaucoma

Trial design

30 participants in 1 patient group

intervention

Other group

Description:

medication: duloxetine 30 to 60 mg tablets by mouth, QD to BID.

Treatment:

Drug: Duloxetine