Efficacy and Safety of Ethanol Lock Therapy for the Prevention of Central Line-associated Bloodstream Infections

Stanford University

Status: Terminated

Conditions: Catheter-Related Infections

Treatments: Other: Heparin lock; Other: Ethanol lock

Study type: Interventional

Funder types: Other

Identifiers

NCT02890875

38195

Details and patient eligibility

About

Patients on long-term parenteral nutrition (PN) are at high risk for central line-associated bloodstream infections (CLABSI). This study evaluates the efficacy and safety of ethanol lock therapy for CLABSI prophylaxis in adult patients on PN.

Enrollment: 3 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (ages 18-80) on PN with silicone-based central venous catheters

Exclusion criteria

• Weight ≤ 50 kg
• Allergy/hypersensitivity/intolerance to ethanol or heparin
• Pregnancy or breastfeeding
• Patient taking metronidazole, disulfiram, or isoniazid
• History of alcohol abuse
• History of heparin-induced thrombocytopenia (HIT) or have an active hypocoagulable state

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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3 participants in 2 patient groups

Ethanol lock

Active Comparator group

Description:

70% ethanol

Treatment:

Other: Ethanol lock

Heparin lock

Active Comparator group

Description:

Heparinized saline (100 U/mL)

Treatment:

Other: Heparin lock