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Efficacy and Safety of Ethanol Lock Therapy for the Prevention of Central Line-associated Bloodstream Infections

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Stanford University

Status

Terminated

Conditions

Catheter-Related Infections

Treatments

Other: Heparin lock
Other: Ethanol lock

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Patients on long-term parenteral nutrition (PN) are at high risk for central line-associated bloodstream infections (CLABSI). This study evaluates the efficacy and safety of ethanol lock therapy for CLABSI prophylaxis in adult patients on PN.

Enrollment

3 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Adult patients (ages 18-80) on PN with silicone-based central venous catheters

Exclusion criteria

  • Weight ≤ 50 kg
  • Allergy/hypersensitivity/intolerance to ethanol or heparin
  • Pregnancy or breastfeeding
  • Patient taking metronidazole, disulfiram, or isoniazid
  • History of alcohol abuse
  • History of heparin-induced thrombocytopenia (HIT) or have an active hypocoagulable state

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

3 participants in 2 patient groups

Ethanol lock
Active Comparator group
Description:
70% ethanol
Treatment:
Other: Ethanol lock
Heparin lock
Active Comparator group
Description:
Heparinized saline (100 U/mL)
Treatment:
Other: Heparin lock

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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