Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis

MiKS Hospital

Status

Enrolling

Conditions

Knee Osteoarthristis

Treatments

Other: Platelet Rich Plasma

Study type

Interventional

Funder types

Other

Identifiers

NCT07329361

UCA-17/EC/25/CON

Details and patient eligibility

About

Evaluation of intra-articular injections in knee osteoarthritis using frozen-stored PRP. Compared with intra-articular injections of PRP applied at the time of collection.

Enrollment

60 estimated patients

Sex

All

Ages

40 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients of both sexes.
Aged between 40 and 85 years old.
Diagnosed with osteoarthritis through clinical radiological examination.
Joint pain equal to or less than 75 points on the KOOS (pain).
Radiological severity grades 1, 2, and 3 according to the Ahlbäck scale.
Indication for intra-articular PRP infiltration.
Body Mass Index values between 20 and 35.
Negative serological tests for syphilis, HIV, HBV, and HCV.
Possibility of observation during the follow-up period.
Signature of informed consent.

Exclusion criteria

Body mass index >35
Diagnosed polyarticular disease.
Previous arthroscopy in the last year.
Severe mechanical deformity.
Intra-articular hyaluronic acid injection in the last 12 months.
Intra-articular corticosteroid or PRP injection in the last 6 months.
Systemic autoimmune rheumatic disease (connective tissue diseases and systemic necrotizing vasculitis).
Anemia or other hematological disorders.
Positive serological tests for SYPHILIS, HIV, HBV, and HCV.
Undergoing immunosuppressive treatments.
Poorly controlled diabetes mellitus.
Patients allergic to paracetamol.
Pregnancy or breastfeeding.