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Efficacy and Safety of Intralesional 5-Fluorouracil and Triamcinolone Acetonide in Keloids and Hypertrophic Scars

M

Maharajgunj Medical Campus

Status

Completed

Conditions

Keloids

Treatments

Drug: Intralesional 5-fluorouracil
Drug: Intralesional Triamcinolone 5 mg/ml

Study type

Observational

Funder types

Other

Identifiers

NCT07034482
54(6-11)E2.077/078

Details and patient eligibility

About

Pathological scars like keloids and hypertrophic scars (HTS's) cause significant aesthetic, symptomatic and psychological issues to patients. Treatment is challenging with no universally accepted "gold standard" method. Plethora of options is in practice: intralesional (IL) injections, silicon sheets, lasers, cryotherapy, radiotherapy and surgery. This study analysed the effect of combination therapy of IL 5-fluorouracil (5-FU) and triamcinolone acetonide (TAC) in keloids and HTS's.

Enrollment

41 patients

Sex

All

Ages

16+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients aged 16 years or more, with keloids or hypertrophic scar more than 10 mm in size

Exclusion criteria

  • Signs of systemic or local infection
  • who underwent treatment for same scar in the past 6 months
  • Renal failure or liver dysfunction or bone marrow suppression

Trial design

41 participants in 1 patient group

Patients aged 16 years or more, with keloids and HTS's more than 10 mm in size
Treatment:
Drug: Intralesional Triamcinolone 5 mg/ml
Drug: Intralesional 5-fluorouracil

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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