Efficacy and Safety of Ivabradine on Top of Atenolol in Stable Angina Pectoris (ASSOCIATE)

Servier

Status and phase: Completed; Phase 3

Conditions: Angina Pectoris

Treatments: Drug: Ivabradine

Study type: Interventional

Funder types: Other

Identifiers

NCT00202566

CL3-16257-057

Details and patient eligibility

About

To test whether ivabradine when given in combination with atenolol is able to improve the exercise tolerance of patients with stable angina pectoris

Enrollment: 750 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic stable angina pectoris
• Documented coronary artery disease
• Previous treatment with atenolol or other beta-blocker agent
• Exercise tolerance test positivity and stability

Exclusion criteria

• Heart rate < 60 bpm
• Congestive heart failure