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Efficacy and Safety of Lumen Apposing Metal Stents (LAMS)

I

Istituto Clinico Humanitas

Status

Enrolling

Conditions

Biliary Obstruction

Treatments

Device: Lumen apposing metal stent (LAMS)

Study type

Observational

Funder types

Other

Identifiers

NCT03903523
970 (Other Identifier)

Details and patient eligibility

About

Endoscopic ultrasonography (EUS) has revolutioned the management of gastroenterological patients and is acquiring an increasingly important role.

The development of specifically designed stents has significantly increased the technical and clinical success rate of the EUS-guided procedures, considerably reducing the rate of adverse events. Currently EUS has a prominent role in drainage of peripancreatic fluid collections and it represents an important therapeutic option for patients with distal malignant biliary obstruction, in which the ERCP fails, allowing the positioning of a transgastric or transbulbar lumen apposing metal stent (LAMS) to drain the biliary duct. Moreover, the EUS-guided gallbladder drainage of patients with high surgical risk and acute cholecystitis, which cannot be operated, is another important therapeutic indication.

Our aim is to perform a multicentre retrospective analysis of all types of EUS drainage (gallbladder drainage, biliary drainage, peripancreatic fluid collection drainage) with the positioning of LAMS in order to evaluate the rate of technical and clinical success and to assess the safety profile of these procedures.

Enrollment

500 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age ≥18 years
  • Patients with distal malignant common bile duct obstruction with failed ERCP
  • Patients with symptomatic peripancreatic fluid collections
  • Patients with acute cholecystitis who are unfit for surgery
  • Agree to receive follow up phone calls
  • Able to provide written informed consent

Exclusion criteria

  • Coagulation and/or platelets hereditary disorders.
  • Pregnant women
  • Inability to sign the informed consent

Trial contacts and locations

2

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Central trial contact

Andrea Anderloni, MD; Alessandro Fugazza, MD

Data sourced from clinicaltrials.gov

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