Efficacy and Safety of Oral Ibrexafungerp (SCY-078) vs. Placebo in Subjects With Acute Vulvovaginal Candidiasis (Vanish 306)

Scynexis

Status and phase: Completed; Phase 3

Conditions: Candida Vulvovaginitis

Treatments: Drug: Placebo; Drug: Ibrexafungerp

Study type: Interventional

Funder types: Industry

Identifiers

NCT03987620

SCY-078-306

Details and patient eligibility

About

This is a Phase 3, randomized, multicenter, double-blind, placebo-controlled study to evaluate the efficacy and safety of oral Ibrexafungerp (SCY-078) compared to placebo in female subjects 12 years and older with AVVC.

Full description

Subjects who meet all of the inclusion and none of the exclusion criteria will be enrolled into the study and will be randomized in a 2:1 ratio to either oral ibrexafungerp or ibrexafungerp matching placebo, as follows:

• Oral ibrexafungerp 300-mg dose BID (bis in die) for 1 day
• Oral ibrexafungerp matching placebo BID for 1 day

This is a randomized, double-blind study.

Approximately 366 eligible subjects will be enrolled and randomized in a 2:1 ratio to one of the two study treatment groups. Subjects will be followed for assessments of efficacy and safety for approximately one month after study drug administration. The design of this study is identical to VANISH 303 Study: NCT03734991

Enrollment: 455 patients

Sex: Female

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subject is a postmenarchal female subject 12 years and older
• Subject has a diagnosis of symptomatic AVVC at baseline including a positive microscopic examination with 10% Potassium Hydroxide (KOH) in a vaginal sample revealing yeast forms (hyphae/pseudohyphae) or budding yeasts, and vaginal pH (≤4.5)

Exclusion criteria

• Subject has any vaginal condition other than AVVC that may interfere with the diagnosis or evaluation of response to therapy, such as suspected or confirmed concurrent causes of vulvovaginitis and/or cervicitis (mixed infection)
• Need for systemic and/or topical (vaginal) anti fungal treatment, including prescription or over-the-counter products during the study and treatment for vulvovaginal candidiasis (VVC) 28 days prior to randomization.
• Subject has uncontrolled diabetes mellitus.
• Subject has a vaginal sample with pH >4.5.
• Subject has a history of or an active cervical/vaginal cancer.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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455 participants in 2 patient groups, including a placebo group

Ibrexafungerp (SCY-078)

Experimental group

Description:

300 mg BID for one day

Treatment:

Drug: Ibrexafungerp

Placebo

Placebo Comparator group

Description:

Matching Placebo

Treatment:

Drug: Placebo