Efficacy and Safety of the ELIOS Laser in Combined Cataract and Glaucoma Surgery

Hôpital Privé de la Baie

Status

Not yet enrolling

Conditions

Glaucoma

Treatments

Device: Surgery with ELIOS laser

Study type

Interventional

Funder types

Other

Identifiers

NCT06760169

2024-32-PDB

Details and patient eligibility

About

Glaucoma is an irreversible optic neuropathy. It is the second most common cause of blindness worldwide. Glaucoma can be treated with topical medications (eye drops), laser or surgery. Traditional surgery is invasive and has a high complication rate (hypotonia, endophthalmitis, cataracts, etc.). As a result, several types of micro-invasive surgery (MIGS) have been developed to reduce the risks of surgery while maintaining their effectiveness in lowering intraocular pressure (IOP). The ELIOS laser system is the only ophthalmological excimer laser designed for the surgical treatment of glaucoma. The aim of the procedure is to ablate the trabecular meshwork and inner wall of Schlemm´s canal ab interno, with the creation of 10 microchannels of 210 um in the trabeculum using the ELIOS laser with a wavelength of 308 nm, in order to improve trabecular outflow to achieve a reduction in IOP. The ELIOS laser is an example of Microinvasive Glaucoma surgery (MIGS) with published results demonstrating efficacy and safety. The ELIOS laser is already in use in France (AMM / CE mark achieved). Its use as part of a prospective interventional study will enable us to collect data in order to treat patients more effectively and improve the quality of care provided to glaucoma patients.

Enrollment

46 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients ≥ 18 years of age who agree to take part in the study and have signed an informed consent form
Visually significant cataract with indication for surgery
Primary open-angle glaucoma, or secondary open-angle glaucoma (pseudoexfoliative glaucoma or pigmentary glaucoma) with indication for cataract surgery.
Open iridocorneal angle (Shaffer classification grade 2-4)
Early to moderate glaucoma (advanced glaucoma, with MD from VFs worse than -12dB, will be excluded)

Exclusion criteria

Presence of severe systemic pathologies 2024-A01891-46_Protocol_V6_21112024_Elios Page 20 / 58
Pregnant or breastfeeding women
<18 years of age
Presence of other ophthalmological pathologies (except cataracts), and exclusion of severe dry eye.
History of intraocular surgery, trauma, or conjunctival scarring in the quadrant intended for surgery
Visual acuity worse than "counting fingers".
Closure of the iridocorneal angle (and angle-closure glaucoma), angle-closure glaucoma secondary to iridocorneal synechiae, neovascular glaucoma or neovascularization of the iris.
Normal-pressure glaucoma
Pachymetry < 490 um or > 620 μm
Glaucomatous visual field with mean deviation worse than ≤-12 dB
IOP > 35 mmHg
Autoimmune disorder, especially collagenosis
Patient under protective supervision
Patient not covered by a social security scheme