Efficacy and Safety of the Liquid Embolic System (Tonbridge) for Endovascular Treatment of Cerebrovascular Malformations

Zhuhai Tonbridge Medical Technology

Status

Enrolling

Conditions

Intracranial Arteriovenous Malformations

Treatments

Device: Liquid Embolic System (Tonbridge)

Device: Onyx Liquid Embolic System (Medtronic)

Study type

Interventional

Funder types

Industry

Identifiers

NCT06479343

SZTQ202401

Details and patient eligibility

About

The purpose of this study is to verify the efficacy and safety of the Liquid Embolic System (Tonbridge Medical Tech. Co., Ltd. (Suzhou)) for the treatment of cerebrovascular malformations.

Full description

This is a prospective, multi-center, randomized, parallel positive controlled, non-inferiority trial. This clinical trial is conducted at more than 2 centers in China, and patients who intend to be treated with liquid embolic system for cerebrovascular malformations are enrolled. Eligible patients are randomized into experimental group using Liquid Embolic System (Tonbridge) or control group using Onyx Liquid Embolic System (Medtronic) in a 1:1 ratio. The purpose of this study is to evaluate the effectiveness and safety of the Liquid Embolic System (Tonbridge).

Enrollment

170 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age 18 to 80 years, any gender;
Subject is suitable for endovascular treatment of cerebrovascular malformations;
Subject is able to understand the purpose of the study, shows sufficient compliance with the study protocol and provides a signed informed consent form.

Exclusion criteria

Intracranial hemorrhage within 1 month prior to treatment;
The targeted embolization area needs to receive other treatments (surgical resection, SRS, other embolic materials) at the same time;
Combination of other cerebrovascular malformations, such as cavernous vascular malformation;
Severe stenosis or occlusion of cerebral feeding artery requiring surgical intervention;
Intracranial tumor requiring surgical intervention;
mRS score≥3;
Heart, lung, liver and renal failure or other severe diseases;
Known bleeding tendency, such as coagulation dysfunction (INR>1.5);
Known allergy to DMSO and contrast media, or contraindication to anticoagulant therapy;
Pregnant or breastfeeding women, or who plan to become pregnant during the study;
Subject is participating in other drug or medical device clinical trials at the time of signing informed consent;
Other conditions judged by the investigators as unsuitable for enrollment.