Efficacy and Safety of Unripe Bokbunja Extract on Improvement of Blood Cholesterol

Yonsei University

Status: Completed

Conditions: Blood Cholesterol

Treatments: Dietary Supplement: unripe Bokbunja Extract; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03649620

BC_cholesterol

Details and patient eligibility

About

This study was conducted to investigate the effects of daily supplementation of unripe Bokbunja extract on improvement of blood cholesterol.

Full description

This study was a 12 weeks, randomized, double-blind, placebo-controlled human trial. Forty subjects were randomly divided into unripe Bokbunja extract 600 mg or placebo group. The investigators measured total cholesterol, lipid profile, arteriosclerosis index, anthropometric index, oxidized LDL.

Enrollment: 80 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age between 20 and 65 years,
• Total cholesterol 200-239 mg/dl
• subjects giving written informed consent

Exclusion criteria

• Cardiovascular disease, e.g. arrhythmia, heart failure, myocardial infarction
• History of disease that could interfere with the test products or impede their absorption, such as gastrointestinal disease or gastrointestinal surgery
• Participation in any other clinical trials within past 2 months
• Laboratory test, medical or psychological conditions deemed by the investigators to interfere with successful participation in the study
• Pregnancy or breast feeding etc,.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups, including a placebo group

unripe Bokbunja Extract

Experimental group

Description:

tablet(1 tablet/d, 600 mg/d) for 12 weeks

Treatment:

Dietary Supplement: unripe Bokbunja Extract

Dietary Supplement: Placebo

Placebo

Placebo Comparator group

Description:

Placebo for 12 weeks

Treatment:

Dietary Supplement: unripe Bokbunja Extract

Dietary Supplement: Placebo