Efficacy and Safety of Using Combination of 755-nm Picosecond Alexandrite Laser and 2% Hydroquinone Compared With 2% Hydroquinone Alone for the Treatment of Melasma: a Randomized Split-face Controlled Trial

Mahidol University

Status: Unknown

Conditions: Melasma

Treatments: Drug: topical 2% hydroquinone; Device: 755-nm picosecond alexandrite laser with topical 2% hydroquinone

Study type: Interventional

Funder types: Other

Identifiers

NCT04597203

si 082/2019

Details and patient eligibility

About

This study aims to assess the efficacy and safety of using combination of 755-nm picosecond alexandrite laser and 2% hydroquinone compared with 2% hydroquinone alone for the treatment of melasma: A randomized split-face controlled trial

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Both male and female age 18-60 years
• Melasma on both cheeks - epidermal or mixed type
• Fitzpatrick Skin type III-V

Exclusion criteria

• History of retinoid or other keratolytic drugs used within 6 months before enrolled
• History of keloid
• photosensitivity
• Immunocompromised host

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups

split face - left side

Experimental group

Treatment:

Device: 755-nm picosecond alexandrite laser with topical 2% hydroquinone

split face - right side

Active Comparator group

Treatment:

Drug: topical 2% hydroquinone