Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors (innovaTV 207)

Seagen

Status and phase: Enrolling; Phase 2

Conditions: Exocrine Pancreatic Cancer; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Carcinoma, Squamous Cell of Head and Neck

Treatments: Drug: cisplatin; Drug: carboplatin; Drug: tisotumab vedotin; Drug: pembrolizumab

Study type: Interventional

Funder types: Industry

Identifiers

NCT03485209

2023-503812-34 (Registry Identifier)

2017-005076-26 (EudraCT Number)

MK-3475-E02 (Other Identifier)

SGNTV-001

KEYNOTE-E02 (Other Identifier)

Details and patient eligibility

About

This trial will study tisotumab vedotin to find out whether it is an effective treatment alone or with other anticancer drugs for certain solid tumors and what side effects (unwanted effects) may occur. There are seven parts to this study.

• In Part A, the treatment will be given to participants every 3 weeks (3-week cycles).

• In Part B, participants will receive tisotumab vedotin on Days 1, 8, and 15 every 4-week cycle.

• In Part C, participants will receive tisotumab vedotin on Days 1 and 15 of every 4-week cycle.

• In Part D, participants will be given treatment on Day 1 of every 3-week cycle. Participants in Part D will get tisotumab vedotin with either:

  • Pembrolizumab or,
  • Pembrolizumab and carboplatin, or
  • Pembrolizumab and cisplatin

• In Part E, participants will receive tisotumab vedotin on Days 1 and 15 of every 4-week cycle.

• In Part F, participants will receive tisotumab vedotin on Days 1, 15, and 29 of every 6-week cycle. Participants in Part F will get tisotumab vedotin with pembrolizumab.

• In Part G, participants will receive tisotumab vedotin on Days 1, 15, and 29 of every 6-week cycle. Participants in Part G will get tisotumab vedotin with pembrolizumab and carboplatin.

Full description

The primary goal of this trial is to assess the activity, safety, and tolerability of tisotumab vedotin for the treatment of selected solid tumors. Patients will be treated with single agent tisotumab vedotin or tisotumab vedotin in combination with other anticancer agents. Patients who meet eligibility criteria will be enrolled into cohorts based on tumor type. Tumor types to be evaluated include colorectal cancer, squamous non-small cell lung cancer (sqNSCLC), exocrine pancreatic adenocarcinoma, and head and neck squamous cell carcinoma (HNSCC).

Enrollment: 692 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parts A, B, and C

  • Relapsed, locally-advanced or metastatic colorectal or pancreatic cancer, sqNSCLC, or HNSCC participants who are not candidates for standard therapy.

  • All participants must have experienced disease progression on or after their most recent systemic therapy.

  • Colorectal cancer (closed to enrollment): participants must have received prior therapy with each of following agents, if eligible: a fluoropyrimidine, oxaliplatin, irinotecan, and/or bevacizumab. Participants should have received no more than 3 systemic regimens in the metastatic setting.

  • sqNSCLC (closed to enrollment): Participants with NSCLC must have predominant squamous histology. Participants must have received prior therapy with a platinum-based treatment and a checkpoint inhibitor (CPI), if eligible. Participants should have received no more than 3 lines of systemic therapy in the metastatic setting.

    • Participants eligible for a tyrosine kinase inhibitor should have received such therapy. These participants should have received no more than 4 lines of systemic therapy in the metastatic setting.

  • Exocrine pancreatic adenocarcinoma (closed to enrollment): Participants with exocrine pancreatic adenocarcinoma must have predominant adenocarcinoma histology. Participants must have received prior therapy with a gemcitabine-based or 5FU-based regimen, if eligible, and should have received no more than 1 systemic regimen in the unresectable or metastatic setting.

  • HNSCC (closed to enrollment): Participants with HNSCC in Part C must have received prior therapy with a platinum-based regimen and/or a checkpoint inhibitor (CPI), if eligible, and must have experienced disease progression following such therapy. Participants should have received no more than 3 systemic lines of therapy in the recurrent or metastatic setting.

• Part E

  • Participants with HNSCC must have experienced disease progression on or after their most recent systemic therapy. Participants should have received no more than 1 or 2 systemic lines of therapy in the recurrent/metastatic setting as specified below. Participants must have received a platinum-based regimen and a PD-(L)1 inhibitor.

• Parts D, F, and G

  • Part D is closed to enrollment. Part F and Part G will enroll only participants with HNSCC.

  • Participants with HNSCC must have received no previous systemic therapy in the recurrent or metastatic disease setting.

  • Part D only

    • Participants with NSCLC must have histologically or cytologically documented squamous cell NSCLC and must have received no previous systemic therapy for metastatic disease or radiation therapy to the lung that is > 30 Gy within 6 months of the first dose of study treatment.
    • PD-L1 biomarker expression as determined by a PD-L1 IHC assay should be available

  • Part F only

    • Participants must have CPS ≥1 by local PD-L1 IHC assay to be eligible for enrollment. Participants must be able to submit a tissue sample for retrospective PD-L1 testing. Tissue may be fresh biopsy or archival, collected within 2 years of Cycle 1 Day 1.

  • Part G only

    • Non-EU eligibility criteria: No CPS requirement for the cohort evaluating tisotumab vedotin in combination with pembrolizumab and carboplatin.
    • EU-specific eligibility criteria: Participants must have a CPS ≥1 by local PD-L1 IHC assay.
    • Participants must be able to submit a tissue sample for retrospective PD-L1 testing. Tissue may be fresh biopsy or archival, collected within 2 years of Cycle 1 Day 1.

• Baseline measurable disease as measured by RECIST v1. 1.

• Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1.

Exclusion criteria

• Participants with primary neuroendocrine or sarcomatoid histologies. For HNSCC, participants may not have a primary site of nasopharynx or salivary gland.
• Active bleeding conditions
• Ocular surface disease at the time of enrollment (Note: cataract is not considered active ocular surface disease for this protocol)
• Other cancer: known past or current malignancy other than inclusion diagnosis.
• Uncontrolled tumor-related pain
• Inflammatory lung disease. Participants with pulmonary disease are allowed if systemic steroids and long-term oxygen are not required
• Peripheral neuropathy greater than or equal to Grade 2
• Active brain metastasis
• Ongoing clinically significant toxicity associated with prior treatment (including radiotherapy or surgery).
• Part D, F, and G Only: Prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

692 participants in 7 patient groups

Part A: Tisotumab Vedotin - Q3W Schedule

Experimental group

Description:

Tisotumab Vedotin on Day 1 of every 21-day cycle in participants with various solid tumors in 2L+

Treatment:

Drug: tisotumab vedotin

Part B: Tisotumab Vedotin - 3Q4W Schedule

Experimental group

Description:

Tisotumab Vedotin on Days 1, 8, and 15 of 28-day cycle in participants with various solid tumors in 2L+

Treatment:

Drug: tisotumab vedotin

Part C: Tisotumab Vedotin - 2Q4W Schedule

Experimental group

Description:

Tisotumab Vedotin on Days 1 and 15 of every 28-day cycle in participants with HNSCC or sqNSCLC in 2L+

Treatment:

Drug: tisotumab vedotin

Part D: Tisotumab Vedotin Combination Therapy - Q3W Schedule

Experimental group

Description:

Tisotumab Vedotin + pembrolizumab + (carboplatin or cisplatin). Given on Day 1 of every 21-day cycle in participants with various solid tumors in 1L HNSCC or sqNSCLC

Treatment:

Drug: pembrolizumab

Drug: tisotumab vedotin

Drug: cisplatin

Drug: carboplatin

Part E: Tisotumab Vedotin - 2Q4W Schedule

Experimental group

Description:

Tisotumab Vedotin on Days 1 and 15 of every 28-day cycle in participants with HNSCC in the second- or third-line setting

Treatment:

Drug: tisotumab vedotin

Part F: Tisotumab Vedotin Combination Therapy - Q2W Schedule

Experimental group

Description:

Tisotumab Vedotin + pembrolizumab. Tisotumab Vedotin given on Days 1, 15, and 29 of every 6-week cycle. Pembrolizumab given on Day 1 of every 6-week cycle in participants with HNSCC in the first line setting

Treatment:

Drug: pembrolizumab

Drug: tisotumab vedotin

Part G: Tisotumab Vedotin Combination Therapy - Q2W Schedule

Experimental group

Description:

Tisotumab Vedotin + pembrolizumab + carboplatin. Tisotumab Vedotin and carboplatin given on Days 1, 15, and 29 of every 6-week cycle. Pembrolizumab given on Day 1 of every 6-week cycle in participants with HNSCC in the first line setting

Treatment:

Drug: pembrolizumab

Drug: tisotumab vedotin

Drug: carboplatin