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Efficacy and Tolerability of Hirudoid Cream in Prophylaxis and Treatment Infusion Phlebitis

M

Medinova

Status and phase

Completed
Phase 3

Conditions

Thrombophlebitis
Phlebitis

Treatments

Drug: Placebo cream without active substance
Drug: Hirudoid cream 0.3 % Mucopolysaccharide polysulfate

Study type

Interventional

Funder types

Industry

Identifiers

NCT01943006
Hir-901113

Details and patient eligibility

About

Patients receiving nutritional emulsion for at least 3 days will be treated with Hirudoid cream or placebo cream to prevent and treat phlebitis caused by the infusion. The treatment is continued after the end of infusion for at least 7 days.

Number of patients developing superficial phlebitis and duration of phlebitis will be recorded.

Enrollment

144 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients who are admitted to the hospital requiring to receive infusion of a complete nutritional emulsion for 3 days (Kabiven® Peripheral, 1400 kcal, 1920 ml, 750 mosmol/L, pH 5.6),
  • Aged 18-65 years.
  • Patients who are able to understand the requirements of the study and agree to sign an informed consent, approved by an Independent Ethic Committee (IEC)/Institutional Review Board (IRB), prior to the study.

Exclusion criteria

  • Patients known to be allergic to Hirudoid or any ingredients of Hirudoid
  • Patients with impaired skin integrity caused by lesion or soft tissue trauma
  • Patients having skin lesions with ulcerations or any other severe dermatologic disease
  • Patients has been received a complete nutritional emulsion infusion within 7 days of inclusion
  • Patients with severe uncontrolled medical conditions, which makes it undesirable or unsafe for the patients to participate in the study, such as: Acute or chronic uncontrolled severe infections,Unstable angina pectoris, symptomatic congestive heart failure, myocardial infarction, serious uncontrolled cardiac arrhythmia or any other clinically serious cardiac disease, Uncontrolled diabetes as defined by fasting serum glucose > 1.5 x ULN; optimal glycaemic control should be achieved before starting trial therapy, Uncontrolled bleeding
  • Patients known to have coagulation disorders such as Haemophilia, Thrombocytopenia, Thrombosis, Other severe hematologic conditions like leukaemia, especially with abnormal coagulation
  • Patients who have symptoms of microangiopathy (small vessel disease) or neuropathy related to diabetes and other diseases
  • Patients with hyperthyroidism and hypothyroidism
  • Patients who are pregnant or breast feeding
  • Patients who are on anticoagulant therapy (last 2 weeks)
  • Patients with severe psychiatric conditions
  • Patients who are unable to bear legal responsibility or unable to understand the study
  • Patients who are unreliable or unable to comply with the protocol, like alcohol or drug abusers
  • Patients who had been participated in another clinical trial in the past 12 weeks
  • Patient is relatives of, or staff directly reporting to, the investigator
  • Patient is employee of the sponsor

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

144 participants in 2 patient groups, including a placebo group

Hirudoid cream
Experimental group
Description:
Patient treated with Hirudoid cream 0.3% Mucopolysaccharide polysulfate Twice daily
Treatment:
Drug: Hirudoid cream 0.3 % Mucopolysaccharide polysulfate
Placebo
Placebo Comparator group
Description:
Patients treated with placebo cream without active substance Twice daily
Treatment:
Drug: Placebo cream without active substance

Trial contacts and locations

4

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Data sourced from clinicaltrials.gov

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