Efficacy and Tolerance of Therapeutic Apheresis in Paediatric Neurology: a French Multicenter Study

University Hospital Center (CHU)

Status: Completed

Conditions: Apheresis Related Complication

Treatments: Other: Efficacy of apheresis

Study type: Observational

Funder types: Other

Identifiers

NCT04845516

RECHMPL21_0084

Details and patient eligibility

About

After developing in pediatric hematology and nephrology, therapeutic apheresis is increasingly used in pediatric neurology despite a sparse level of evidence.

There are a few retrospective series with a small number of patients, concerning mainly autoimmune diseases (encephalitis, myasthenia gravis, polyradiculoneuritis).

The objective of this work is to study therapeutic apheresis (including plasma exchange and immunoadsorption) among french neuropediatric tertiary centers and to prove that this treatment modality is effective and well tolerated in pediatric neurology diseases.

Full description

Multicenter medical data collection :

• Montpellier
• Toulouse
• Bordeaux
• Marseille
• Nancy
• Paris Kremlin Bicêtre
• Paris Robert Debré
• Paris Necker
• Paris Trousseau
• Lyon
• Besançon
• Rennes
• Reims
• Strasbourg
• La Réunion
• Nantes
• Tours

Enrollment: 200 patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children under 18.
• Supported in a participating CHU between 2014 and 2019.
• Having benefited from therapeutic apheresis (plasma exchanges and immunoadsorption) in a neuropediatric indication

Exclusion criteria

• Family or patient refusal to participate

Trial design

200 participants in 2 patient groups

plasma exchange

Description:

All patients underwent plasma exchanges between 2014 and 2019 for a neuropediatric pathology

Treatment:

Other: Efficacy of apheresis

immunoadsorption

Description:

All patients who underwent immunoadsorptions between 2014 and 2019 for a neuropediatric pathology

Treatment:

Other: Efficacy of apheresis