Efficacy Long-term Dietary Nitrate Consumption to Plasma Nitrite Conversion
Status
Conditions
Treatments
Details and patient eligibility
About
The objective of this study was to determine the chronic effects of beetroot juice supplementation on the acute (90-minute post nitrate consumption) efficacy of converting dietary nitrate to plasma nitrate and plasma nitrite in healthy middle-to-older aged adults. the investigators were also interested in determining the effect of this intervention on fasting levels of plasma nitrate and nitrite over time. Furthermore, the number of participants classified as "non-responders" was determined based on increases in plasma nitrite achieved using tolerable volumes of beetroot juice by other studies.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Middle and Older (40-80 year-old) men and women
- Body mass index between 18.5 - 30.0 kg/m2
- Able to provide own transportation to study testing visits
- Able to consume study beverages
- Able to speak and read English
Exclusion criteria
- Tobacco user (smoke or chew), including e-cigarettes
- Known conditions of: diabetes mellitus (type 1 or 2), atrophic gastritis, hypo- or hyperthyroidism, gout, history of kidney stones, history of hypotension, cardiovascular disease, chronic obstructive pulmonary disease, inflammatory bowel diseases, impaired liver or kidney function
- Current or recent (last 3 months) treatment for cancer
- Current use of the following medications: Phosphodiesterase type 5 inhibitors, nitroglycerin or nitrate preparations, proton pump inhibitors, medication for hypothyroidism, antacid and heartburn medications
Trial design
Primary purpose
Allocation
Interventional model
Masking
13 participants in 2 patient groups, including a placebo group
Trial contacts and locations
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal