Efficacy of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild to Moderate Acne Vulgaris

Combined Military Hospital Abbottabad

Status: Completed

Conditions: Acne Vulgaris

Treatments: Drug: 30% salicylic acid; Drug: 25% TRICHLOROACETIC ACID

Study type: Interventional

Funder types: Other

Identifiers

NCT05712837

CMHAtd-ETH-15-Derm-22

Details and patient eligibility

About

To compare the efficacy of 25% trichloroacetic acid peel versus 30% salicylic acid peel in mild to moderate acne vulgaris.

Study Design: Randomized Control Trial. Place And Duration of Study: Department of Dermatology, CMH Abbottabad from 01 Jun 2022 to 30th Nov, 2022.

Methodology: A total of 60 patients presented with mild or moderate acne vulgaris were randomized into two groups comprising 30 patients in each group and treated with either the TCA peel or the SA peel at 2-week intervals for 12 weeks. Patients in Group A were treated with 25% TCA peel whereas patients in Group B were treated with 30% SA peel. At the end of therapy after 12 weeks, evaluation of active acne was done by individual lesion counts (comedones, papules and pustules) and calculation of the Michaelsson acne score (MAS).

Enrollment: 60 patients

Sex: All

Ages: 13 to 22 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with mild or moderate facial acne vulgaris presented in dermatology opd

Exclusion criteria

• Patients with grade III or IV acne vulgaris
• patients taking any acne medications or had taken oral or topical medications in the past 4 weeks
• pregnant female patients or nursing a baby
• patients with known hypersensitivity to the formulations used in the study or a history of photosensitivity
• hypertrophic scars, keloidal tendency, active or recurrent herpes simplex infection
• active dermatosis
• unrealistic expectations

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Group A 25% TCA

Active Comparator group

Description:

25% TCA peel Patients of group A were treated with 25% TCA peel and patients at 2-week intervals for a total of 12 weeks. Clinical evaluation was done at the end of therapy after 12-weeks of treatment.

Treatment:

Drug: 25% TRICHLOROACETIC ACID

Group B 30% SALICYLIC ACID

Active Comparator group

Description:

30% SA peels Patients of group B were treated with 30 % salicylic acid peel and patients at 2 weeks interval for a total of 12 weeks.clinical evaluation was done at the end of therapy after 12 weeks of treatment

Treatment:

Drug: 30% salicylic acid