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Efficacy of a Combined Transcranial Direct Current Stimulation and Virtual Reality Intervention (REACT01)

H

Hospitales Nisa

Status

Completed

Conditions

Stroke
Upper Limb Injury
Hemiparesis
Chronic Stroke

Treatments

Device: REACt system
Other: Physical therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT03528018
TIN2014-61975-EXP (Other Grant/Funding Number)
BES-2014-068218 (Other Grant/Funding Number)
NISA-PHYS-2016/1

Details and patient eligibility

About

Rehabilitation options for stroke survivors who present severe hemiparesis in chronic stages are limited and may end in compensation techniques that involve the use of the less affected arm to achieve some degree of functional independence. Transcranial direct current stimulation (tDCS) is a non-invasive technique that has been used after stroke to promote excitability of the surviving neural architecture in order to support functional recovery. Interestingly, cortical excitability has been reported to increase when tDCS is combined with virtual reality. This synergetic effect could explain the promising results achieved by preliminary experimental interventions that combined both approaches on upper limb rehabilitation after stroke. The objective of this study is to explore the use of these interventions in subjects with severe hemiparesis and to determine its efficacy in comparison to conventional physical therapy

Enrollment

14 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • chronicity > six months
  • severe paresis of the upper limb defined by the Brunnstrom Approach as stages I or II and by the Upper Extremity subscale of the Fugl-Meyer Assessment as scores below 19
  • ability to maintain a sitting position for at least 60 minutes
  • fairly good cognitive condition defined by scores in the Mini-Mental State Examination above 23.

Exclusion criteria

  • pacemakers
  • brain implants or other metallic objects (valves, coils, etc.)
  • impaired comprehension that hinder sufficient understanding of the instructions defined by Mississippi Aphasia Screening Test scores below 45
  • severe visual impairments
  • emotional or behavioral circumstances that impede adequate collaboration

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

14 participants in 2 patient groups

Control
Other group
Description:
Conventional physical therapy
Treatment:
Other: Physical therapy
Experimental
Experimental group
Description:
Combined tDCS and VR-based intervention
Treatment:
Other: Physical therapy
Device: REACt system

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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