Efficacy of a Mouthwash Containing Propolis (PRO)

Federal University of Minas Gerais

Status and phase: Unknown; Phase 3

Conditions: Periodontitis; Inflammation; Plaque; Gingivitis

Treatments: Drug: Propolis; Drug: chlorhexidine

Study type: Interventional

Funder types: Other

Identifiers

NCT01750801

Propolis

Details and patient eligibility

About

Characterization of green propolis and development of mouthwash containing propolis to control plaque and gingivitis. A Phase I.

Full description

Chemical characterization of propolis by HPLC (High-performance liquid chromatography), antimicrobial testing against pathogens and cariogenic. Studies in vitro on anti-inflammatory activity, cytotoxicity tests of green propolis.

Enrollment: 2 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age ranging from 18 to 60 years
• minimum of 20 natural teeth
• mean plaque index (PI)of at least 1.5
• an average gingival index (GI), at least less than 1.0.

Exclusion criteria

• Individuals with orthodontic appliances or removable dentures,
• Individuals whit tumors of soft tissue or hard mouth, and advanced periodontal disease,
• Indivuduals whit antibiotic therapy 2 weeks prior to study initiation, or with known hypersensitivity propolis are also excluded.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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2 participants in 2 patient groups

Propolis

Active Comparator group

Description:

alcohol-free mouthwash containing 5% green propolis (MGP 5%) on the control of plaque and gingivitis.

Treatment:

Drug: chlorhexidine

chlorhexidine

Active Comparator group

Description:

chlorhexidine used on the control of plaque and gingivitis.

Treatment:

Drug: Propolis