Efficacy of a Rinse Containing Sea Salt and Lysozyme on Biofilm and Gingival Health

University of Saskatchewan

Status

Completed

Conditions

Chronic Gingivitis

Chronic Gingivitis, Plaque Induced

Treatments

Other: Standardized Oral Health Practices

Other: Sea Salt Mouth Rinse

Study type

Interventional

Funder types

Other

Identifiers

NCT03329105

16-272

Details and patient eligibility

About

This study evaluates the addition of a mouth rinse containing sea salt, xylitol and lysozyme to standardized oral health practices on biofilm formation and gingival health in a group of young adults.

Full description

The purpose of this study is to evaluate a new sea salt mouth rinse containing xylitol and the antibacterial enzyme, lysozyme on biofilm formation and gingival health in a group of young adults. Xylitol is a well-established non-sugar sweetener and an anti-caries agent. The use of this polyol results in loosely adherent biofilms by reducing the amount of extracellular lipopolysaccharides and lipoteichoic acids, facilitating its easy removal by mechanical means. Lysozymes are antibacterial proteins that hydrolyze the linkage between N-acetylmuramic acid and N-acetylglucosamine of peptidoglycan in the cell wall of Gram + bacteria effectively limiting growth.

Enrollment

30 patients

Sex

All

Ages

20 to 26 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Dentate
Medically healthy
No orthodontic bands
An anticipated ability to attend the two scheduled visits

Exclusion criteria

Significant medical condition (including but not limited to, poorly controlled diabetes mellitus, rheumatic heart disease or clinically significant heart murmur)
Pregnancy
Recent history of, or ongoing, antibiotic therapy