Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section

Seoul National University

Status and phase: Enrolling; Phase 4

Conditions: Postoperative Pain; Cesarean Section

Treatments: Drug: Acetaminophen; Drug: Acetaminophen/Ibuprofen

Study type: Interventional

Funder types: Other

Identifiers

NCT06479122

2405-052-1535

Details and patient eligibility

About

The investigators aim to compare the analgesic efficacy of intravenous acetaminophen alone versus combination of acetaminophen/ibuprofen (Maxigesic®IV) in multimodal analgesia after cesarean section.

Enrollment: 84 estimated patients

Sex: Female

Ages: 19+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients scheduled for elective cesarean section
• Gestational age > 37+0 weeks

Exclusion criteria

• Emergency cesarean section
• Multiple pregnancy (e.g. twins, triplets)
• Body weight < 50 kg
• Preeclampsia
• History of hypersensitivity to acetaminophen or ibuprofen
• History of upper gastrointestinal tract bleeding or gastric ulcer
• Underlying liver disease
• Underlying kidney disease or GFR < 90 mL/min/1.73m2
• Heart failure or severe hypertension
• History of asthma
• Chronic use of barbital or tricyclic antidepressants

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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84 participants in 2 patient groups

Acetaminophen

Active Comparator group

Treatment:

Drug: Acetaminophen

Drug: Acetaminophen

Acetaminophen/Ibuprofen

Experimental group

Treatment:

Drug: Acetaminophen/Ibuprofen

Drug: Acetaminophen/Ibuprofen