Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Laparoscopic Gynecology Surgery

The Catholic University of Korea

Status: Enrolling

Conditions: Gynecologic Disease

Treatments: Drug: Ibuprofen; Drug: Acetaminophen

Study type: Interventional

Funder types: Other

Identifiers

NCT05509244

acetaminophen-ibuprofen

Details and patient eligibility

About

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen only and 2) acetaminophen and ibuprofen combination at postoperative pain after laparoscopic gynecologic surgery.

Full description

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen 1g only and 2) the combination of acetaminophen 1g and ibuprofen 300mg at postoperative pain after laparoscopic gynecologic surgery. Some recovery valuables such as the postoperative pain and opioid requirements will be assessed.

Enrollment: 64 estimated patients

Sex: Female

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled gynecologic laparoscopic surgery

Exclusion criteria

1. Refusal to be enrolled in the study
2. Emergency surgery
3. On chronic pain medications
4. Psychiatric disorders
5. Pregnant, lactating women
6. Allergy or contraindication to the medication drugs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

64 participants in 2 patient groups

control group

Active Comparator group

Description:

acetaminophen 1g iv dripping

Treatment:

Drug: Acetaminophen

experimental group

Experimental group

Description:

the combination of acetaminophen 1g and ibuprofen 300mg iv dripping

Treatment:

Drug: Ibuprofen

Drug: Acetaminophen