Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Thyroidectomy

The Catholic University of Korea

Status: Enrolling

Conditions: Thyroid Disease

Treatments: Drug: Acetaminophen; Drug: Ibuprofen

Study type: Interventional

Funder types: Other

Identifiers

NCT05626010

AAP-ibuprofen-thyroid

Details and patient eligibility

About

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen only and 2) acetaminophen and ibuprofen combination at postoperative pain after thyroidectomy.

Full description

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen 1g only and 2) the combination of acetaminophen 1g and ibuprofen 300mg at postoperative pain after thyroidectomy. Some recovery valuables such as the postoperative pain and opioid requirements will be assessed

Enrollment: 62 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• the patients undergoing scheduled thyroidectomy
• American Society of Anesthesiologists status 1 or 2

Exclusion criteria

• refusal to be enrolled in the study
• emergency surgery
• hepatic or renal disease
• on chronic pain medications
• psychiatric disorders
• pregnancy, lactation
• allergy or contraindication to the study drug

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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62 participants in 2 patient groups

control group

Active Comparator group

Description:

acetaminophen 1g iv dripping

Treatment:

Drug: Acetaminophen

experimental group

Experimental group

Description:

the combination of acetaminophen 1g and ibuprofen 300mg iv dripping

Treatment:

Drug: Ibuprofen

Drug: Acetaminophen