Efficacy of Acupuncture and Moxibustion Treatment in Patients With Quiescent Crohn's Disease:Evaluation With fMRI

Shanghai Institute of Acupuncture, Moxibustion and Meridian

Status: Completed

Conditions: Crohn's Disease; CAM

Treatments: Other: moxibustion; Other: electroacupuncture

Study type: Interventional

Funder types: Other

Identifiers

NCT01696838

SHACU-201201

Details and patient eligibility

About

The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of Crohn's disease. Meanwhile, the investigators aim to evaluate the efficacy by functional magnetic resonance imaging.

Full description

The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of Crohn's disease. meanwhile, the investigators aim to evaluate the efficacy by functional magnetic resonance imaging.

Through treating quiescent Crohn's disease by electroacupuncture or moxibustion therapies for 12 weeks, Compare the different brain activation by the different therapies and observe the correlation between brain activation and efficacy.

Enrollment: 61 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18-50 years;
• right-handed;
• clinical remission (Crohn's Disease Activity Index [CDAI]≤150) for at least 6 months prior to the study;
• C-reactive protein(CRP)<10 mg/l;
• erythrocyte sedimentation rate (ESR) <20 mm/h
• signing awritten informed consent form.

Exclusion criteria

• use of corticosteroids and psychotropic medications in the previous 30 days;
• current or prior history of neurological or psychiatric disease based
• on physicians' examination and questionnaires;
• current or prior history of neurosurgery, head injury, cerebrovascular
• insult, or brain trauma involving loss of consciousness;
• learning disability;
• claustrophobia;
• presence of metallic implants in the body;
• being pregnant or during lactation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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61 participants in 2 patient groups

EA group

Experimental group

Description:

Electroacupuncture group

Treatment:

Other: electroacupuncture

Other: moxibustion

MOX group

Experimental group

Description:

Herbs-partitioned moxibustion group

Treatment:

Other: electroacupuncture

Other: moxibustion