Efficacy of Acute Intake of Ketones on Performance in Professional Road Cyclists (KETA)

Universidad Católica San Antonio de Murcia

Status: Completed

Conditions: Ketoses, Metabolic; Ketosis

Treatments: Dietary Supplement: Ketone monoester; Dietary Supplement: Control product consumption

Study type: Interventional

Funder types: Other

Identifiers

NCT05294939

UCAMCFE-00022

Details and patient eligibility

About

Randomized, controlled, double-blind, crossover clinical trial, depending on the product consumed, to analyze the efficacy on physical performance of a sports supplement consumed prior to and during competition or training.

Full description

Subjects who meet the selection criteria will be randomly assigned to each of the study groups (investigational product or placebo, depending on the group to which they have been assigned). On the second day, participants will consume the product that subjects did not consume on the first day.

The product to be consumed will be ketone monoester. Participants will consume 800 mg/kg body weight, distributed in two intakes. The first one, half an hour before exercise and the same dose will be consumed one hour and a half after the first dose. The intakes will be accompanied by carbohydrates and bicarbonate.

The tests that the cyclists will perform are a time trial on a cycloergometer to measure performance, as well as a 30" sprint. Afterwards, the cyclists will do a 4 and a half hour training session at competition pace. After this training session, the participants will do the same time trial and the 30'' sprint.

Enrollment: 29 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male professional cyclists.
• Start the study with previous rest.

Exclusion criteria

• Participant suffering from chronic illness.
• Suffering a long-term injury that prevents her from training in the month prior to the intervention.
• Inability to understand the informed consent.
• Having consumed ketone bodies chronically in the previous four weeks.
• To have undergone cholecystectomy.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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29 participants in 2 patient groups, including a placebo group

Ketone monoester

Experimental group

Description:

Consumption of 800mg/kg body weight of ketone monoester, divided in two intakes. The mixture will be prepared with bicarbonate. In addition, every hour they should consume 90g of carbohydrates.

Treatment:

Dietary Supplement: Ketone monoester

Control product

Placebo Comparator group

Description:

Consumption of placebo product (carbohydrates) masked with citric, divided in two intakes. The mixture will be prepared with bicarbonate. In addition, every hour they should consume 90g of carbohydrates.

Treatment:

Dietary Supplement: Control product consumption