Efficacy of Adding Azithromycin to Cephalosporin Before Cesarean Delivery

Ain Shams University

Status and phase: Completed; Phase 4

Conditions: Wound Sepsis

Treatments: Drug: Azithromycin Tablets; Drug: cephalosporin

Study type: Interventional

Funder types: Other

Identifiers

NCT04062175

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Details and patient eligibility

About

efficacy of adding azithromycin to cephalosporin before cesarean delivery

Full description

efficacy of adding azithromycin to cephalosporin for the prophylaxis against infectious morbidity following cesarean delivery in high risk women

Enrollment: 144 patients

Sex: Female

Ages: 17 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age between 17 and 39 years
• gestaional age between 37 to 42 weeks
• elective cesarean delivery
• obese women

Exclusion criteria

• diabetic women on corticosteroids
• intraopertaive complication in previous section
• history of septic woun
• prelabour rupture of membrane >12 hours

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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144 participants in 2 patient groups

cephalosporin arm

Active Comparator group

Description:

72 women will receive single antibiotic chemotheraby first generation cephalosporin (cefazolin) 2 gm iv within 30 minutes before skin incision

Treatment:

Drug: cephalosporin

cephalosporin +azithromycin arm

Active Comparator group

Description:

72 women will receive combined antibiotic chemotherapy azithromycin (Azrolid) 1 gm single oral dose 2 hours before cesarean delivery + cephalosporin(Cefazolin) 2 gm iv within 30 minutes before skin incision

Treatment:

Drug: cephalosporin

Drug: Azithromycin Tablets