Efficacy of Allergen Immunotherapy for Allergic Rhinitis in Thais

Pongsakorn Tantilipikorn

Status and phase: Completed; Phase 4

Conditions: Rhinitis, Allergic, Perennial

Treatments: Other: Control; Biological: Intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT01115595

336/2552

Details and patient eligibility

About

The purpose of this study is to study the efficacy of allergen injection immunotherapy for allergic rhinitis by

• symptoms score
• medication score
• quality of life
• immunologic test from blood

Full description

Compare the efficacy of allergen injection immunotherapy between the treatment group and the placebo group after injection for

• 2 months
• 6 months
• 12 months

Enrollment: 84 patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with the symptoms of allergic rhinitis who sensitized to mite (Dermatophagoides pteronyssinus)
• positive skin prick test to D.p. at 4+ degree

Exclusion criteria

• steroid dependent asthma
• force expiratory volume (FEV1) less than 70% of predicted value
• previous injection immunotherapy within 2 years
• pregnancy
• medical conditions such as ischemic heart disease, autoimmune disease, cancer, previous history of anaphylaxis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Quadruple Blind

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84 participants in 2 patient groups

Intervention

Active Comparator group

Description:

injection by Mite extract with standard allergic medication (oral antihistamine and/or topical nasal steroid)

Treatment:

Biological: Intervention

Control Group

Other group

Description:

Injection by buffer solution WITH standard allergic medication (oral antihistamine and/or topical nasal steroid

Treatment:

Other: Control