Efficacy of Antihistamine Dosing-up and add-on Treatment With H2-receptor Antagonist (OPEhRA)

Ajou University School of Medicine

Status: Completed

Conditions: Chronic Urticaria

Study type: Observational

Funder types: Other

Identifiers

NCT03293225

AJIRB-MED-OBS-17-173

Details and patient eligibility

About

A randomized open labeled trial to compare the efficacy of antihistamine dosing-up and add-on treatment with H2-receptor antagonist in patients with chronic urticaria

Full description

• For four weeks
• After the researcher confirms the selection / exclusion criteria on the baseline, the UAS, K-UCT, and CU-QoL are created and randomized from the subject.
• Receive UAS, K-UCT, and CU-QoL from the subject during the last visit to assess safety

Enrollment: 110 patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adolescents and adults over 12 years
• Clinical diagnosis of chronic urticaria due to wheal reaction, itching, angioedema over 6 weeks
• Antihistamine 2 or 2 kinds of treatment for more than 2 weeks even if the symptoms are not controlled
• Those who do not have other chronic skin diseases

Exclusion criteria

• None

Trial design

110 participants in 4 patient groups

add H2RA

Description:

Add antihistamines to standard drug therapy

change ns-H1RA

Description:

Change to ns-H1RA in standard medication

ns-H1RA(3-4 tabs)

Description:

Standard treatment with ns-H1RA 4X dose

ns-H1RA(3-4kinds)

Description:

Use of NS 4 kinds for standard treatment